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Release date：2019-07-31

JACI

[IF:13.1]

Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort
DOI: https://doi.org/10.1016/j.jaci.2019.05.036
Abstract
Background
Cockroach is one of the most important sources of indoor allergens that can lead to IgE sensitization and to the development of rhinitis and asthma.
Objective
To perform a cockroach allergen component analysis to determine the allergens and antibody levels and patterns of sensitization that are associated with asthma and rhinitis.
Methods
Antibody levels (IgE, IgG and IgG4) to total cockroach and to eight cockroach allergens were determined in two groups of cockroach sensitized 10-year old children with (n = 19) or without (n = 28) asthma and rhinitis. Allergen-specific antibody levels were measured in streptavidin ImmunoCAPs loaded with each of the recombinant allergens from groups 1, 2, 4, 5, 6, 7, 9, and 11, and total cockroach-specific IgE was measured using the i6 ImmunoCap.
Results
IgE antibody levels to cockroach allergens and extract, but not IgG or IgG4, differed between subjects with and without asthma and rhinitis. Specifically, recognition of more cockroach allergens, with higher allergen-specific IgE, were associated with disease. Variable patterns of sensitization, with no immunodominant allergens, were found in both groups. There was a good correlation between the sum of allergen-specific IgE and total cockroach IgE (r = 0.86; p <0.001).
Conclusions
Component analysis of eight cockroach allergens revealed significant differences in IgE reactivity associated with the presence of asthma and rhinitis. Allergen-specific IgE titers and sensitization profiles were associated with asthma and rhinitis.
All Author:
Anna Pomés Jill Glesner Agustin Calatroni Cindy M. Visness Robert A. Wood George T. O’Connor Meyer Kattan Leonard B. Bacharier Lisa M. Wheatley James E. Gern William W. Busse
· Genome Institute of Singapore, Agency for Science, Technology and Research Singapore, Singapore

2019-6-16 Article